GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| UCEC | cis | rs2143950 | 1 | rs28399702 | chr14:35625217 | PPP2R3C | chr14:35554679-35591679:- | 0.49 | 4.5 | 1.35E-5 | Atopic dermatitis |
| UCEC | cis | rs9815354 | 1 | rs28733681 | chr3:41863444 | ULK4 | chr3:41288091-42003660:- | 0.45 | 5.21 | 6.03E-7 | Diastolic blood pressure |
| UCEC | cis | rs10935120 | 1 | rs2887797 | chr3:134202506 | ANAPC13 | chr3:134196547-134204865:- | 0.39 | 4.41 | 1.92E-5 | Height |
| UCEC | cis | rs9309473 | 1 | rs2901438 | chr2:73665656 | ALMS1P | chr2:73872046-73912692:+ | 0.55 | 6.51 | 1.01E-9 | Metabolite levels |
| UCEC | cis | rs2294008 | 1 | rs2920280 | chr8:143761144 | PSCA | chr8:143761875-143764142:+ | 0.39 | 4.37 | 2.25E-5 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2294008 | 1 | rs2920292 | chr8:143765699 | PSCA | chr8:143761875-143764142:+ | 0.42 | 5.2 | 6.34E-7 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2294008 | 1 | rs2920293 | chr8:143765414 | PSCA | chr8:143761875-143764142:+ | 0.41 | 5.1 | 9.99E-7 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2294008 | 1 | rs2920294 | chr8:143765326 | PSCA | chr8:143761875-143764142:+ | 0.42 | 5.2 | 6.34E-7 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2294008 | 1 | rs2920295 | chr8:143764937 | PSCA | chr8:143761875-143764142:+ | 0.37 | 4.63 | 7.95E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2294008 | 1 | rs2920296 | chr8:143763109 | PSCA | chr8:143761875-143764142:+ | 0.41 | 5.18 | 7.05E-7 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2294008 | 1 | rs2920297 | chr8:143763083 | PSCA | chr8:143761875-143764142:+ | 0.41 | 5.18 | 7.05E-7 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2294008 | 1 | rs2920298 | chr8:143763043 | PSCA | chr8:143761875-143764142:+ | 0.41 | 5.18 | 7.05E-7 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |
| UCEC | cis | rs2602836 | 1 | rs2924584 | chr4:99988208 | ADH4 | chr4:100044835-100065449:- | -0.36 | -5.28 | 4.46E-7 | HDL cholesterol |
| UCEC | cis | rs11976180 | 1 | rs2961134 | chr7:143771062 | ARHGEF35 | chr7:143883677-143892736:- | -0.38 | -4.39 | 2.12E-5 | Obesity-related traits |
| UCEC | cis | rs2294008 | 1 | rs2976392 | chr8:143762932 | PSCA | chr8:143761875-143764142:+ | 0.41 | 5.08 | 1.1E-6 | Gastric adenocarcinoma (histologically verified);Non-cardia gastric cancer;Gastric cancer;Duodenal ulcer;Bladder cancer |